As alluded to in Deadpool #8, a mysterious outfit have been harvesting Wade Wilson's regenerating organs for years, and in August's Deadpool #14, three Weapon X/Plus subjects--Deadpool, Wolverine and Captain America--team up to find out the connection between this and the program; and we meet a Weapon X reject with a major mad-on for the Merc with a Mouth!
You can find out more about the arc as co-writer Gerry Duggan and incoming artist-for-the-story Declan Shalvey talk to Marvel.com and Comic Book Resources about their plans here and here!
And as well as this, Deadheads can look forward to the introduction of a Deadpool from a future where Wade's a member of the X-Men(!)--in the forthcoming X-Event, X-Men: Battle of the Atom. And you can find out more about that at Newsarama here!